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Jasco Autosampler High-performance Liquid Chromatograph EXTREMA

Made in Japan
Manufacturer: Jasco
Model: Autosampler : AS-4050, AS-4050i, AS-4150, AS-4250, AS-4058

EXTREMA is a high-performance liquid chromatograph (HPLC) that brings together the best of JASCO’s technology. You can build the optimal system for your purpose from a variety of units, including UHPLC, RHPLC (Rapid Separation HPLC), semi-preparative pumps, and high-sensitivity detectors. The chromatography data system, ChromNAV, renowned for its operability and processing functions, now offers enhanced functionality and user-friendliness with its upgrade to Ver. 2.0. This version includes various improvements, making it more efficient and intuitive for users.

System lineup

There are three types in the lineup: HPLC/RHPLC, UHPLC, and Prep-HPLC. Many units are available, and you can build the optimal system by combining units suited to your purpose.

Autosampler

From the left: HPLC/RHPLC, UHPLC, Prep-HPLC

UHPLC

Ultra High Performance Liquid Chromatography (UHPLC) uses columns packed with ultrafine particles of 2µm or less, enabling separation at high pressure (up to 130 MPa). This method allows for high-speed separation while maintaining high separation efficiency. Compared to conventional HPLC, UHPLC significantly shortens analysis time, reducing it to just 1/5 to 1/10 of the usual duration. Additionally, it minimizes the amount of mobile phase solvent used, cutting it down to nearly 1/10, thus enhancing both efficiency and sustainability.

HPLC/RHPLC

Rapid Separation HPLC (RHPLC) provides a high-speed analysis method that spans the range from conventional HPLC to some UHPLC applications. This analytical system utilizes fully porous packed columns with particle sizes of 2 to 3 µm and core-shell columns. Moreover, it supports measurements in the medium pressure range (30 to 70 MPa), positioning itself as the future standard analytical method.

Prep-HPLC

Preparative High Performance Liquid Chromatography (Prep-HPLC) focuses on isolating and purifying target compounds with high purity from synthetic products and natural substances. EXTREMA, equipped with a semi-preparative pump, enables its use as a semi-preparative high performance liquid chromatograph (Prep-HPLC). Additionally, it facilitates micro- and ultra-micro-preparative separations when integrated with an RHPLC or UHPLC system.

Unit Lineup

One can construct a system by combining a wide range of units according to the intended purpose, allowing for flexibility and customization.

HPLC RHPLC UHPLC Prep-HPLC
pump PU-4185, PU-4180, PU-4085i, PU-4080i, PU-4085B PU-4285, PU-4285B PU-4086, PU-4087, PU-4086B
Detector UV-4070, UV-4075, MD-4010, MD-4015, MD-4017, RI-4030, RI-4035, FP-4020, FP-4025, CD-4095, OR-4090
Autosampler AS-4050, AS-4050i AS-4150 AS-4250 AS-4058
Column Oven CO-4060, CO-4065, CO-4061, CO-4062, RO-4068

Hardware

AS-4050/4050i for HPLC

The basic model AS-4050/4050i serves as the best model for conventional HPLC, holding up to 60 samples. Users can opt for sample cooling. The AS-4050i, an inert type, uses no metal materials in the flow paths that contact the sample solution or mobile phase.

HPLC autosampler AS-4050

AS-4150 for RHPLC, AS-4250 for UHPLC

The high performance models, AS-4150 and AS-4250, offer advanced capabilities. The AS-4150, with a maximum pressure resistance of 70 MPa and a shortest injection time of 30 seconds, suits RHPLC applications. It also supports sample dilution and pre-column operations. The AS-4250, designed for UHPLC, features a maximum pressure resistance of 130 MPa, making it ideal for high-pressure applications.

UHPLC autosampler AS-4250

For preparative use AS-4058

The large volume injection model AS-4058 can inject up to 10mL (standard is 5mL). It is used in combination with semi-preparative pumps such as PU-4087.

Software Features

System control using ChromNAV Ver.2

ChromNAV Ver.2 is an easy-to-use chromatography data system. It fully utilizes the performance of EXTREMA, from controlling the entire system to analyzing measurement results and managing data.
ChromNAV CFR Ver.2 with enhanced data integrity is also available.

HPLC Systems

Data acquisition and analysis using ChromNAV Lite

ChromNAV Lite is a PC integrator with excellent operability. It is specialized for recording and analysis functions, and has high cost performance and a simple and easy-to-understand user interface.

ChromNAVLite

Specification

Autosampler

Model name
AS-4050/AS-4050i AS-4150 AS-4250 AS-4058
Sample injection method Fixed loop method and variable injection amount method (zero sample loss possible) Fixed loop type
Variable injection amount type (zero sample loss possible)
Direct line injection (optional, piping change)
Fixed loop type
Variable injection amount type (zero sample loss possible)
Direct line injection (optional, piping change)
Fixed loop method and variable injection amount method (zero sample loss possible)
Number of samples 60 (2mL vials) 180 (2mL vials) 180 (2mL vials) 40 (20mL vial, standard)
Injection volume setting range *1 0.1 to 100 µL
(Large volume kit: 1 to 1000 µL, optional)
0.1 to 100 µL
(Large volume kit: 1 to 1000 µL, optional)
0.1 to 100 µL
(Large volume kit: 1 to 1000 µL, optional)
1 to 10,000 µL
Sample Loop (Standard) 100µL 20µL 5µL 5000µL
Injection Accuracy RSD 0.3% or less (specified conditions) RSD 0.25% or less (specified conditions) RSD 0.25% or less (specified conditions) RSD 1.0% or less (2500µL, zero sample loss) (specified conditions)
carry-over Less than 0.01% (10µL, specified conditions) Less than 0.01% (2µL, specified conditions)
Less than 0.005% (when optional multiple solvent washing valve is installed) (specified conditions)
Less than 0.01% (2µL, specified conditions)
Less than 0.005% (when optional multiple solvent washing valve is installed) (specified conditions)
0.05% or less (2000µL, zero sample loss) (specified conditions)
0.02% or less (with optional multiple solvent washing valve) (specified conditions)
Maximum Operating Pressure 30MPa (AS-4050)
34MPa (AS-4050i)
70MPa 130MPa 41MPa
Sample temperature control *2 Temperature setting range: 4 to 40°C Temperature setting range: 4 to 40°C Temperature setting range: 4 to 40°C Temperature setting range: 4 to 40°C

*1 Sample loops, etc. may need to be replaced depending on the injection volume.
In the case of a fixed loop system, injection is only possible at the loop volume.
In the case of a variable injection system, the linearity range of the injection volume is 50-60% of the volume of the installed sample loop.

*2 Sample temperature control is an option. A sample temperature control unit is required separately.

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